Product Details:

Sergel is a proton pump inhibitor that inhibits stomach acid production by inhibiting the H+/K+-ATPase in the gastric parietal cell specifically. Esomeprazole (S-isomer of omeprazole) is the first proton pump inhibitor with a single optical isomer that provides superior acid control than racemic proton pump inhibitors. Sergel capsules include an enteric-coated pellet formulation of esomeprazole magnesium for absorption. Peak plasma levels (Cmax) occur around 1.5 hours after oral dosing (Tmax). When the dosage is increased, the Cmax increases proportionately, and the area under the plasma concentration-time curve (AUC) increases thrice from 20 to 40 mg. The systemic bioavailability is around 90% with repeated once-daily dosage, compared to 64% after a single dose. When compared to fasting circumstances, the AUC following a single dosage of esomeprazole is reduced by 33-53 percent after food ingestion. Take esomeprazole at least one hour before meals. Sergel is linked to plasma proteins in 97 percent of cases. Over a concentration range of 2 20 mmol/L, plasma protein binding is constant. In healthy individuals, the apparent volume of distribution at steady state is around 16 L. Metabolism: The cytochrome P450 (CYP) enzyme system extensively metabolizes esomeprazole in the liver. Esomeprazole metabolites have no anti-secretory action. The CYP2C19 isoenzyme, which produces the hydroxy and desmethyl metabolites, is responsible for the majority of esomeprazole metabolism. The remainder is dependent on CYP3A4, which produces the sulphone metabolite.

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Sergel 20